Year: 2026
Type: preprint
Abstract: The timing of BOLD-fMRI is typically chosen such that TE matches T2*. This assumes contrast being exclusively elicited by signal differences at TE. While sensible for short or TE-symmetric readouts, such as EPIs, it oversimplifies contrast generation for longer or TE-asymmetric trajectories, such as spirals. We propose the concept of a BOLD PSF for a more comprehensive perspective on the imaging characteristics of a functional experiment. Our findings indicate that TE can be reduced for spiral-out without sacrificing BOLD-sensitivity when compared to EPI. Furthermore, we characterize the intrinsic trade-off between specificity and resolution of the BOLD response under varying TE.
Source: arXiv (Cornell University)
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7221785129