Work

Discovery and Optimization of Anticancer Dibenzothiazepinones That Target the Ribosome Biogenesis Factor NVL

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c02184

Authors: Ye Tao, Holly H. Guo, Victor E. Cruz, Divya Reddy, Ashley Leach, Noelle S. Williams, Arin B. Aurora, Vishal Khivansara, Yan Han, Jan P. Erzberger, Deepak Nijhawan, Jef K. De Brabander

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Welch Foundation, Cancer Prevention and Research Institute of Texas, University of Texas Southwestern Medical Center

Awards: Benzothiazepines as first-in-class inhibitors for the ribogenesis factor NVL and evaluation in preclinical colorectal cancer models, G308532787, G5619825470, G8514038875

OpenAlex ID: W7221793075

FWCI:

Cites: 25

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