Work

Evaluation of novel 1,4-dihydropyridine spirooxindole as antitumor, anti-inflammatory, and antioxidant agents

Year: 2026

Type: article

Abstract: value in LPS-primed RAW 264.7 macrophages. Distinctively, 6a displayed superior antioxidative capacity in DPPH radical scavenging compared with the others. Collectively these findings highlight 1,4-dihydropyridine spirooxindoles as promising multifunctional leads for anticancer and anti-inflammatory drug development with a high therapeutic safety window.

Source: RSC Advances

DOI: 10.1039/d6ra06965g

Authors: Esraa H. Al-Afghani, Jalal A. Zahra, Mustafa M. El-Abadelah, Areej M. Jaber, Violet Kasabri

Institutions: University of Jordan, Al-Ahliyya Amman University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042