Predictors and Patterns of Metastatic Candidozyma auris Infection, Spain, 2016–2024
Year: 2026
Type: review
Study design: Observational Study
Abstract: Metastatic infection after Candidozyma auris candidemia remains poorly characterized. We retrospectively studied patients with C. auris candidemia at a tertiary hospital in Spain during 2016-2024. Of 108 patients, 24 (22.2%) experienced metastatic infections; endocarditis was most frequent (7.4%), followed by osteoarticular infection, meningitis, and hepatosplenic infection (3.7% each). In multivariable Fine-Gray regression, a cardiac device or prosthetic valve was independently associated with metastatic infection (subdistribution hazard ratio [HR] 2.89 [95% CI 1.21-6.91]), although that association was attenuated in a sensitivity analysis restricted to echocardiographed patients. Persistent candidemia showed a higher, nonsignificant risk for metastatic infection in the day-5 landmark analysis (subdistribution HR 2.67 [95% CI 0.86-8.32]). Metastatic infection was associated with increased deaths in time-dependent analyses at 60 days (adjusted HR 2.21 [95% CI 1.04-4.67]) and 90 days (adjusted HR 2.26 [95% CI 1.09-4.67]). Our findings support echocardiography in patients with intracardiac devices.
Source: Emerging infectious diseases
Authors: Pedro Suarez-Urquiza, Alba Ruiz-Gaitán, Eva Calabuig, María Tasias, Víctor García Bustos, Ignacio Moreno, María Ángeles Ferre, Ana María Moret, Juan Frasquet, Patricio Favier, Javier Pemán, Maria Jesus Castaño-Aroca, Paula Muñoz Brell, Mónica Gordon, Maria Dolores Gomez-Ruiz, Miguel Salavert-Lleti
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7221805078