Work

A dual-switch safety system enables safety controllability and high-efficiency enrichment for T cell immunotherapy

Year: 2026

Type: article

Abstract: locus using a Cas12a/adeno-associated virus (AAV)-mediated delivery platform. Importantly, this dual-switch system enables efficient magnetic bead-based enrichment of tHER2-HSVTK (tHER2-TK)-positive T cells, allows tunable modulation of engineered T cell persistence through Herceptin or the small-molecule drug ganciclovir (GCV), and also provides a highly effective purification method before infusion. Collectively, these features enhance safety without compromising therapeutic efficacy, facilitating the development of safer and more controllable engineered T cell immunotherapies.

Source: Molecular Therapy Advances

DOI: 10.1016/j.omta.2026.201865