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Design and Synthesis of Quinoline Analogues for Hiv-1 Integrase Inhibition to Overcome Resistance and Toxicity

Year: 2026

Type: article

Abstract: The ongoing battle against the human immunodeficiency virus (HIV) has led to significant advancements in antiretroviral therapies, particularly in the development of drugs targeting HIV-1 integrase (IN), an essential enzyme responsible for integrating viral DNA into the host genome. HIV-1 integrase inhibitors (INIs) have shown substantial promise as a therapeutic option, but the emergence of drug resistance and toxicity concerns have significantly hampered their long-term efficacy. This has prompted researchers to explore alternative strategies for designing and synthesizing novel quinoline analogues as potent HIV-1 integrase inhibitors, aimed at overcoming resistance mechanisms and minimizing toxicity.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.23374160

Author: 1*Mr. Dipak G. Garachh, 2Dr. Yakub Pasha Mohammod

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7221816166

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