Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention
Year: 2026
Type: review
Abstract: Conventional adenomas and serrated lesions are two major precursor lesions of colorectal cancer. They arise through distinct carcinogenic pathways, namely the conventional adenoma-carcinoma sequence and the serrated neoplasia pathway. These pathways differ substantially in their underlying molecular mechanisms, implying that the risk factor profiles for the two types of lesions may be different. However, existing evidence remains fragmented, and an integrated comparative synthesis of these differential associations is lacking. In this review, we synthesize and compare current evidence on the mechanistic characteristics and lifestyle, metabolic, and nutritional determinants of conventional adenomas and serrated lesions. By synthesizing the available evidence on the two precursor pathways, this review may contribute to a better understanding of conventional adenomas and serrated lesions, and offer insights for future research into their distinct risk factors, underlying mechanisms, and implications for colorectal cancer prevention.
Source: Frontiers in Public Health
Institution: Hangzhou Normal University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G3757737023
OpenAlex ID: W7221819212