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Synchronized Ablation of Multifocal Tumors Enabled by Multi‐Channel Lanthanide Nanocomposites

Year: 2026
Type: article
Abstract: The multifocal nature of orthotopic breast tumors makes it difficult to treat due to individual tumor differences, requiring multiple therapeutic interventions. Here, a customized therapeutic strategy is presented for multiple tumors by using the same prescription based on a multi-channel lanthanide nanocomposite and orthogonally controlled drug release. The upconversion luminescence of the nanocomposite at different wavelengths can monitor pH-responsive mitoxantrone (MXT) release, reduced glutathione-responsive near-infrared (NIR) absorbance change, and eigen temperature, respectively, allowing modulation of photothermal treatment and temperature-responsive paclitaxel release through customized whole-body irradiation to achieve synchronized ablation of different individual tumors. Small animal experiments confirm multifocal breast tumors can be treated through this customized therapeutic strategy with both high efficiency and low overtherapy risk.
DOI: 10.1002/adma.75392
Authors: Fang Li, Zheng Wei, Francesco G. Mutti, Hong Zhang, Felix F. Loeffler, Yuxin Liu, Xingjun Zhu
Institutions: ShanghaiTech University, Universität Hamburg, Max Planck Institute of Colloids and Interfaces, Hamburg University of Technology, University of Chicago, Shanghai Clinical Research Center
Language: English
Open Access status: hybrid
Estimated APC paid: $6,070
Funders: Natural Science Foundation of Shanghai, University of Chicago, Capital Normal University, Deutsche Forschungsgemeinschaft, National Natural Science Foundation of China, Universiteit van Amsterdam, Bundesministerium für Bildung und Forschung, Max-Planck-Gesellschaft, China Scholarship Council, ShanghaiTech University
OpenAlex ID: W7221821074
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Cites: 19
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