Work

Case Report: EAdi-guided ventilatory management leads to successful extubation in a pediatric myasthenic disorder

Year: 2026

Type: article

Abstract: Monitoring of diaphragmatic electrical activity (EAdi) may provide real-time insight into neural respiratory drive, but data in pediatric myasthenic disease are scarce. We report a 2-year-old girl requiring mechanical ventilation for respiratory failure due to an initial diagnosis of myasthenic syndrome. Following initiation and escalation of pyridostigmine, median EAdi rose from 1.69 to 7.7 µV while ventilatory support was simultaneously reduced, resulting in successful extubation after 5 days. This case illustrates the potential added value of EAdi monitoring alongside conventional ventilator parameters in tracking neuromuscular recovery during weaning.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2026.1893086

Authors: Marjet J. A. M. Braamskamp, Alette A. Koopman, Martin C. J. Kneyber

Institutions: University Medical Center Groningen, Beatrix Kinderziekenhuis, University of Groningen

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801