Work

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

Year: 2026

Type: article

Abstract: This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighting key compound classes, such as 1,4-benzothiazepines, 1,4-dihydropyridines (DHPs), and polyphenol derivatives. Particular emphasis is placed on the relationship between the structural features and the pharmacological activity, efficacy, and therapeutic potential of these compounds.

Source: ChemMedChem

DOI: 10.1002/cmdc.70506

Authors: Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart

Institutions: Fraunhofer Institute for Translational Medicine and Pharmacology, German Centre for Cardiovascular Research, Max Planck Institute for Multidisciplinary Sciences, Universitätsmedizin Göttingen, University of Göttingen

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,150