Work

Organic cage-anchored ultrafine palladium nanoparticles enable direct C(sp2)–H arylation of benzothiazole

Year: 2026

Type: article

Abstract: )-H arylation of benzothiazole with haloarenes, affording diverse 2-aryl benzothiazole derivatives in moderate to excellent yields (72-85%) with a broad substrate scope, with excellent recyclability up to 6 cycles with no Pd leaching as evident from ICP-MS analysis of the filtrate under hot conditions. Further, DLS study of the reaction mixture confirms the retention of the particulate nature of Pd NPs during the course of the reaction, indicating the heterogenous behavour of the catalyst. Moreover, mechanistic insights were obtained through DFT analysis, which supported a plausible pathway involving oxidative addition and reductive elimination during the catalytic cycle. Notably, to the best of our knowledge, this study presents the first example of an organic cage-stabilized palladium nanoparticle-catalyzed C-H activation of benzothiaozole.

Source: RSC Advances

DOI: 10.1039/d6ra06468j