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Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report

Year: 2026

Type: article

Abstract: Introduction: Yolk sac tumors are malignant germ cell tumors that typically arise in the gonads. Although extragonadal cases have been reported, primary involvement of the urinary tract is extremely rare. Case Presentation: A 67-year-old man presented with gross hematuria. Cystoscopy and contrast-enhanced computed tomography revealed a 6-cm bladder mass. Transurethral resection of the bladder tumor was performed. Histopathological and immunohistochemical findings (alpha-fetoprotein, glypican-3, and Sal-like protein 4 positivity) were consistent with a yolk sac tumor without a urothelial carcinoma component. Additional examinations revealed no primary lesions elsewhere, leading to the diagnosis of a primary bladder yolk sac tumor. The patient received four cycles of etoposide and cisplatin chemotherapy and has remained recurrence-free for 2 years. Conclusions: Patients with primary bladder yolk sac tumors, although rare, may achieve favorable outcomes with combined surgical resection and chemotherapy.

Source: IJU Case Reports

DOI: 10.1002/iju5.70282

Authors: Yuki Hashimoto, Kosuke Shimizu, Masayuki Uegaki, Fumihiko Kono, Toru Yoshida

Language: English

Topic: Urinary and Genital Oncology Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,960

OpenAlex ID: W7221925759

FWCI:

Cites: 12

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