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Sex differences in circulating endocannabinoid concentrations during adolescence: Associations with pubertal development

Year: 2026
Type: article
Study design: Observational Study
Abstract: Endocannabinoids contribute to sex-related processes, including puberty. In 1,159 adolescents, females showed significantly lower concentrations than males across five endocannabinoids (AEA, 2-AG, PEA, OEA, and 2-OG). Sex-by-puberty interactions were significant for AEA, PEA, and OEA. Exploratory analyses revealed sex-specific associations between endocannabinoids and self-reported pain, stress, internalizing, and attentional problems.
DOI: 10.1038/s41386-026-02574-0
Authors: Julia M. Evanski, Tristin Smith, Adriene M. Beltz, Esmeralda Hidalgo-Lopez, Christel M. Portengen, Andrew Schrepf, Steven E. Harte, Chelsea M. Kaplan
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $5,290
Funders: National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Nursing Research, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1020259976, G1569016918, G2532175954, G3755973507, G4066048162, G4114440719, G4509755709, G4572089094, G4854430533, G5081895789, G5139799579, G6317901170, G6449322398, G687916792, G6887863799, G7095117837, G7125624957, G7271102572, G7652160222, G771167098, G7919373933, G8281824583, G8638291733, G8762821959, G9000006386, G9000008241, G9000034221, G9000108491, G9000112882, G9000163168, G9000205938, G9000241459, Behavioral and neurobiological predictors of widespread pain in early adolescence and sex-specific trajectories of pain during puberty, G9001302352, G923039674
OpenAlex ID: W7221940265
FWCI:
Cites: 13
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