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Copper‐Catalyzed C–H Insertion of N ‐Heterocycles Into Diazo Arylidene Succinimides

Year: 2026

Type: article

Abstract: Copper(II) triflate is found to be an effective catalyst for the regioselective C–H insertion of heteroaromatic compounds into diazo arylidene succinimide‐based carbene precursors. Preferential C3–H insertion occurs in N ‐substituted and unsubstituted indoles, while selective C2–H insertion occurs when the C3 site is blocked. This technique was extended to other heteroaromatic compounds, such as carbazoles, phenothiazines and pyrrole, and all of them yielded the respective C–H insertion products in good yields.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70890

Authors: Arputharaj Francisgracia, Kannupal Srinivasan

Institution: Bharathidasan University

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Department of Science and Technology, Ministry of Science and Technology, India

OpenAlex ID: W7221948323

FWCI:

Cites: 26

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