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Differences in the clinical profile between isolated lupus anticoagulant and triplepositive antiphospholipid antibody profiles in primary antiphospholipid syndrome

Year: 2026

Type: article

Abstract: In BriefIn Brazilian cohorts, patients with isolated lupus anticoagulant and those with triple-positive profiles exhibited similar clinical outcomes, with no statistically significant differences in the prevalence of venous or arterial thrombosis or in rates of fetal loss and miscarriages.Although triple positivity is typically associated with a worse prognosis, the only notable difference observed was a higher frequency of hydroxychloroquine prescription in this group, likely due to perceived increased risk.These findings suggest that the severity attributed to triple positivity may be largely driven by the presence of lupus anticoagulant itself.Furthermore, the results differ from those reported in other populations, possibly due to the genetic diversity of the Brazilian population, highlighting the need for further comparative studies across antiphospholipid syndrome profiles. ❚ How to cite this article:Azevedo BV, Signorelli F, Balbi GG, Andrade DC.Differences in the clinical profile between isolated lupus anticoagulant and triple-positive antiphospholipid antibody profiles in primary antiphospholipid syndrome.einstein (São Paulo).2026;24:eAO1654. Differences in the clinical profile between isolated lupus anticoagulant and triplepositive antiphospholipid antibody profiles in primary antiphospholipid syndrome❚ Highlights ■ Similar rates of thrombosis and adverse pregnancy outcomes were observed in the lupus anticoagulant-only and triple-positive groups.■ Hydroxychloroquine use was higher in the triple-positive group.■ No statistically significant differences were observed in microvascular findings between the two groups.

Source: Einstein (São Paulo)

DOI: 10.31744/einstein_journal/2026ao1654

Authors: Bruno Verza Azevedo, Flavio Signorelli, Gustavo Guimarães Moreira Balbi, Danieli Castro Oliveira Andrade