Year: 2026
Type: article
Abstract: The One Health approach recognizes the interdependence of human, animal, and environmental health for managing global health challenges. The increasing incidence of zoonotic diseases, antimicrobial resistance, and environmental degradation underscores the relevance of integrated surveillance strategies. In this context, pan-genomics has emerged as a valuable tool for characterizing the genetic diversity of bacterial pathogens across hosts, geographic regions, and ecological niches. By distinguishing core from accessory genome components, pan-genomic analyses inform vaccine target identification through reverse vaccinology; elucidate antimicrobial resistance determinants; and reveal host adaptation mechanisms. This review examines the application of pan-genomics within the One Health framework, focusing on bacterial pathogens of relevance to human, animal, and environmental health, including Bacillus anthracis , Mycobacterium bovis , Corynebacterium pseudotuberculosis , Mycobacterium marinum , Leptospira interrogans , Yersinia pestis , Francisella tularensis , Corynebacterium ulcerans , and Vibrio vulnificus . For each pathogen, we discuss available genomic data, pan-genome characteristics, and implications for surveillance, diagnostics, and intervention strategies. Additionally, we address the role of metagenomics in environmental monitoring and the contribution of computational approaches, such as reverse vaccinology and subtractive genomics, to the development of novel therapeutic and prophylactic targets.
Authors: Andrei Giacchetto Felice, Sandeep Tiwari, Diego Lucas Neres Rodrigues, Arun Kumar Jaiswal, Rodrigo Bentes Kato, Franciele Maboni Siqueira, Wylerson Guimarães Nogueira, Rodrigo Dias Oliveira Carvalho, Roberta Torres Chideroli, Ulisses de Pádua Pereira, Selma Soares de Oliveira, Sheila da Silva, Thaís Vilela Rodrigues, Pedro Henrique Marques, Fabiana Vieira Dominici, Eduarda Sousa Guimarães, Victor Augusto Sallum Ceballos, Roberto Montes de Oca Jiménez, Aristóteles Góes Neto, Mateus Matiuzzi da Costa, Flávia Figueira Aburjaile, Rommel Ramos, Vasco Azevedo, Siomar de Castro Soares
Institutions: Universidade Federal do Triângulo Mineiro, Universidade Federal de Minas Gerais, Universidade Federal da Bahia, Universidade Federal de Alfenas, Universidade Federal do Rio Grande do Sul, King Abdullah University of Science and Technology, Universidade Estadual de Londrina, Universidade Federal do Rio de Janeiro, Microbiologie de l’alimentation au service de la santé, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Universidade de Ribeirão Preto, Universidade de São Paulo, Universidad Autónoma del Estado de México, Universidade Federal do Vale do São Francisco, Universidade Federal do Pará, Institut Pasteur de São Paulo
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G2684845391, G8693839560
OpenAlex ID: W7222050996