Preregistration: Natural versus artificial rewiring of the Drosophila head-direction connectome
Year: 2026
Type: other
Abstract: Trained recurrent networks constrained by the Drosophila head-direction circuit lose heading memory when 10-25% of their connections are rewired. Wiring differences between individual flies, measured across four connectomes (male CNS, hemibrain, FlyWire, BANC), are of similar size. We test whether networks trained on one fly's wiring keep working on another fly's wiring without retraining (a wiring transplant), at the cell-type and neuron level, whether failure scales with wiring distance between flies, and whether trained networks maintain heading with a ring-like slow manifold.
Author: YAD, MD ALI ASHRAF
Institution: Xiaomi (China)
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7222080901
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