Work

Molecular Diagnosis of Melanocytic Neoplasia: Updates and Challenges

Year: 2026

Type: article

Abstract: Distinction of melanoma from less aggressive melanocytic neoplasms is essential to avoid over- or undertreatment. Melanocytic neoplasms can harbor a broad spectrum of molecular drivers, including mutations, amplifications, and fusions, associated with an array of morphologies and biologic behavior. This molecular complexity creates challenges for classification and diagnosis of malignancy. Here, we review current knowledge to present a molecular framework for classifying melanocytic neoplasia and describe current molecular testing modalities useful for informing accurate diagnosis in challenging cases.

Source: Cancers

DOI: 10.3390/cancers18203330

Authors: Jaclyn M. Plotzke, Grace Wang, Scott C. Bresler, Paul W. Harms

Institutions: University of Michigan, Michigan Medicine, U-M Rogel Cancer Center

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499