Contrast media extravasation following CT angiography in a patient with lower-extremity atherosclerotic occlusive disease: a case report
Year: 2026
Type: article
Study design: Case Report
Abstract: Contrast media extravasation (CME) is a recognized complication of intravenous iodinated contrast administration during computed tomography (CT) examinations, with a reported incidence rate ranging between 0.1% and 1.2%. Although most extravasation injuries are mild and self-limiting, a small proportion of them progress to skin blistering, tissue necrosis, or compartment syndrome. Blister formation, in particular, is an uncommon manifestation observed predominantly in moderate-to-severe extravasation. Herein, we report a case of iobitridol extravasation that occurred during lower-extremity CT angiography in a 68-year-old female patient with lower-extremity atherosclerotic occlusive disease. Approximately 5 h after the procedure, multiple fluid-filled skin blisters developed at the forearm injection site. A combined external regimen-topical Hirudoid (mucopolysaccharide polysulfate) cream, intermittent ice compresses, and Jinhuang San (Golden Yellow Powder) mixed with green-tea water as a wet poultice was applied immediately. The blisters were absorbed by the following day without skin breakdown, and complete resolution was achieved within 48 h. To our knowledge, this is the first report describing this specific three-component topical combination for iobitridol extravasation presenting with blistering. This case highlights the importance of early recognition and structured topical management of CME and suggests-at the hypothesis-generating level-that integrating a traditional Chinese medicine external therapy with conventional topical agents may be a useful option for such injuries. Prospective, controlled studies are required to confirm these observations.
Source: Frontiers in Medicine
Authors: CongBing Yan, Ting Zhang, Qin Xu, Shiyuan Bi
Institution: Tongji University
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7222198433