Work

Microbiome-driven precision psychiatry: integrating multi-omics, artificial intelligence, and personalized interventions along the gut-brain axis

Year: 2026

Type: review

Abstract: Introduction: This scoping review maps evidence for microbiome-driven precision psychiatry in depression and anxiety. Methods: Following JBI guidance and PRISMA-ScR, we searched PubMed/MEDLINE and PubMed Central from inception to July 2026, supplemented by Google Scholar and backward citation searching. Human primary studies were screened and charted; findings were synthesized narratively. Results: Of 58 identified records, 49 remained after deduplication, 35 full texts were assessed, and 28 studies were included. The evidence was predominantly observational. Taxonomic findings varied across populations, while studies of microbial functions, metabolites, multi-omics signatures, and treatment response suggested potential for biological stratification. Microbiome-targeted interventions and artificial intelligence models remain exploratory. Discussion: Microbiome-derived biomarkers and predictive models require standardized methods, independent validation, and prospective evidence of clinical utility before routine psychiatric use.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1957715

Authors: Yi Zhang, Changyong Pei, Daohua Zhang, Jun Liu

Institutions: Changde Vocational Technical College, Xiangya Hospital Central South University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801