Comment on “Duration of antibiotic therapy: with or without biomarkers?”: applying the double-trigger approach at the bedside
Year: 2026
Type: article
Abstract: Antimicrobial resistance has emerged as a critical global health challenge.Significant variability in antibiotic prescribing practices underscores the urgent need for high-quality evidence to inform optimal antibiotic prescribing policies.The ideal duration of antimicrobial therapy remains uncertain, and a one-size-fits-all approach is far from ideal.In this review, we examine bacterial growth kinetics and antibiotic pharmacodynamics and explore various strategies for determining the duration of antibiotic therapy: fixed duration, biomarker-guided, clinical course-based, and the more recent double-trigger approach.
Source: Acute and Critical Care
DOI: 10.4266/acc.007748
Authors: Faruk Yıldız, Volkan İnal
Institution: Trakya University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7222296855
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