Work

Organocatalytic Reaction of α‐(3‐Isoindolinonyl) propargylic Alcohols With 3‐Aminoindoles for Construction of δ‐Carbolines

Year: 2026

Type: article

Abstract: An efficient TFA ‐catalyzed cascade transformation of α‐(3‐isoindolinonyl)propargylic alcohols with 3‐aminoindoles has been developed for the de novo synthesis of multisubstituted δ‐carbolines. This one‐pot protocol integrates a series of sequential steps, including dehydration, 1,4‐addition, isomerization, Claisen rearrangement, aromatization, and ring‐opening, to deliver δ‐carbolines derivatives in a highly efficient manner. Notably, this work not only provides a powerful strategy for the de novo construction of these complex polycyclic scaffolds but also significantly expands the synthetic utility of α‐(3‐isoindolinonyl)propargylic alcohols.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70918

Authors: Yuqing Zhang, Lunfeng Chen, Pengfei Li

Institution: Southern University of Science and Technology

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Southern University of Science and Technology

Award: G3033052602