Year: 2023
Type: dissertation
Study designs: Systematic Review, Meta-Analysis
Abstract: The heartbeat evoked potential (HEP) is considered a neurophysiological indicator of interoception.It has also been observed that various clinical conditions can disrupt interoceptive awareness, leading to the suggestion that HEP amplitudes could serve as valuable biomarkers of interoception.Nevertheless, there is limited understanding regarding how HEP is affected by different conditions and which parameters are most indicative of pathology.We synthesised the current evidence for abnormal HEP amplitudes across all available clinical subpopulations using a random-effects multilevel meta-analysis.We extracted latency window, reference, and scalp electrode topographies, and systematically characterised them across studies (OSF Doi: 10.17605/OSF.IO/TMQ3W).A subgroup analysis by diagnostic group revealed a significant effect in neurological (g = -0.513)and cardiovascular (g = -0.818)groups, indicative of reduced HEP amplitudes relative to healthy comparisons.There was no effect of psychiatric condition on HEP (g = 0.049).HEP amplitude appears to be reduced in people with neurological or cardiovascular conditions but not in people with psychiatric conditions.However, methodological inconsistencies and shortcomings raise questions over the extent and nature of these observations.
Author: Wilkinson, Erica
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7222375075