Work

Thioethers as alkyl donors in electrochemical C–O and C–N bond forming reactions

Year: 2026

Type: preprint

Abstract: A catalyst- and fluoride-free electrochemical method for the use of readily available thioethers as alkyl donors in C-O and C-N bond formation to furnish ethers, esters, and N-alkylated products is reported. The protocol exhibits broad functional group tolerance and is compatible with structurally complex substrates. Cyclic voltammetry studies rationalize the distinct behaviour of oxygen and nitrogen nucleophiles and guide the optimization of the electrochemical conditions, enabling the formation of coupled products from starting materials with both matched and mismatched redox potentials.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15010581/v1

Authors: Malin Lill, Caterina Momoli, Valerio Morlacci, Linn Andersson, Willy Giaccio, Helena Lundberg, Laura Palombi, laura palombi

Institutions: KTH Royal Institute of Technology, University of L'Aquila

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: European Commission, Vetenskapsrådet, Università degli Studi dell'Aquila, Stiftelsen för Strategisk Forskning, NextGenerationEU

Awards: G1713655687, G2406753216, G4881873141, G539632367, Reductive Electrosynthesis - a Radical Approach, G8070073089, Electrochemically driven lanthanide catalysis for reductive activation of organic compounds, G903117326

OpenAlex ID: W7222398008

Cites: 73

Cited by:

Related to: 10