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ANGPT2 promotes angiogenesis and immunosuppressive microenvironment in colorectal cancer

Year: 2026

Type: article

Abstract: Background: The Angiopoietin-Tie2 system is crucial in tumor angiogenesis for colorectal cancer (CRC), while investigations into integrating angiopoietin-Tie2 into the booming immunotherapy are underway. Here, we investigated the expression patterns and prognostic value of the Angiopoietin-Tie2 system in CRC. Methods: . Results: . Conclusions: ANGPT2, rather than ANGPT1, likely plays a significant role in vascular regulation and immune landscape in CRC.

Source: Journal of Gastrointestinal Oncology

DOI: 10.21037/jgo-2025-1-965

Authors: Chunhui Chen, Sufen Wei, Zhiqiang Peng, Shaohua Li, Lu Han, Wei Fang, Yi Cheng, Jianfeng Zheng, Aling Wang

Institutions: Guangdong Provincial Hospital of Chinese Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Guangzhou University of Chinese Medicine

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7222499264

FWCI:

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