Investigation of the Relationship Between Epstein-Barr Virus and Serum Magnesium Levels in Lymphoma Patients
Year: 2026
Type: article
Study design: Observational Study
Abstract: Investigation of the Relationship Between Epstein-Barr Virus and Serum Magnesium Levels in Lymphoma PatientsAim: Lymphoma pathogenesis involves complex interactions of genetic, environmental, and immunological factors.While Epstein-Barr virüs (EBV) is recognized as a contributing factor in several lymphoma subtypes, and magnesium is essential for immune regulation.This study investigated the relationship between serum magnesium levels and EBV positivity in lymphoma patients, and the impact of magnesium on survival.Methods: This retrospective study included 108 lymphoma patients.Demographic, clinical, EBV status, and serum magnesium levels were collected.Statistical analyses, including the chi-square test, Kaplan-Meier estimation, and receiver operating characteristic curve analysis, were performed.Results: Serum magnesium levels were significantly lower in EBV-positive patients (1.82 mg/dL) compared to EBV-negative patients (1.98 mg/dL) (p=0.049).Patients with magnesium levels ≤1.68 mg/dL had significantly shorter overall survival and disease-free survival, particularly in Hodgkin lymphoma (HL).In diffuse large B-cell lymphoma, diminished magnesium levels were associated with inferior survival outcomes.Low magnesium levels were also associated with advanced disease stage (p=0.006).Conclusion: Lower serum magnesium concentrations in lymphoma patients are associated with EBV positivity and poorer survival, particularly within the HL subgroup.Magnesium levels may be associated with prognosis in lymphoma patients; however, larger prospective studies are needed to determine their independent prognostic value.
Institution: Atatürk University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7222531504