Work

Next-Generation Neutral Sphingomyelinase-2 Inhibitors with Improved Solubility, Pharmacokinetics, and Efficacy in a Tau Propagation Model

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c02429

Authors: Arina Ranjit, Lukáš Tenora, Meixiang Huang, Ying Wu, Ajit G. Thomas, Chae Bin Lee, Jesse Alt, Ruoning Zhang, Robert M. Maragakis, Yuxin Zheng, Yu Su, Peter Pietri, Taeyoon Jung, Barbara S. Slusher, Rana Rais

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institute on Aging, National Institute of General Medical Sciences

OpenAlex ID: W7222697159

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Cites: 53

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