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Associations of Antibodies Against Several Infections With Alzheimer Disease Neuropathology

Year: 2026

Type: article

Study design: Observational Study

Abstract: BACKGROUND AND OBJECTIVES: Associations of common infections with Alzheimer disease (AD) risk have been reported. A hypothesized mechanism for these is cerebral β-amyloid (Aβ) aggregation as a defense to infection. We studied whether serologic measures of several infections in the UK population are associated with measures of AD neuropathology. METHODS: ε4 carriage, education, and sex, and for interactions between herpes simplex virus 1 exposure with cytomegalovirus (CMV) and varicella zoster virus (VZV) exposure. RESULTS: ). DISCUSSION: ε4 carriage and education in relation to AD neuropathology warrants further study.

Source: Neurology

DOI: 10.1212/wnl.0000000000218584

Authors: Caterina Felici, Rebecca E. Green, Charlotte Warren-Gash, Julia Butt, Tim Waterboer, Alun Hughes, Nishi Chaturvedi, Ashvini Keshavan, William Coath, Jonathan M. Schott, Marcus Richards, Dylan M. Williams

Institutions: MRC Unit for Lifelong Health and Ageing, University College London, London School of Hygiene & Tropical Medicine, German Cancer Research Center, Heidelberg University, UK Dementia Research Institute

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Wellcome Trust, National Institute for Health and Care Research, British Heart Foundation, Brain Research Trust, University College London, European Commission, UK Dementia Research Institute, Dementias Platform UK, HORIZON EUROPE Framework Programme, Medical Research Council, Economic and Social Research Council, Innovate UK

OpenAlex ID: W7222722663

FWCI: 3.894

Cites: 49

Cited by: 1

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