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Remission of Widespread Erythema Annulare Centrifugum After Empiric Oral Fluconazole in a 54-Year-Old Woman: A Case Report

Year: 2026

Type: article

Abstract: Erythema annulare centrifugum (EAC) is a rare reactive dermatosis that can be difficult to manage in persistent cases.A 54-year-old woman presented with pruritic, annular, and polycyclic plaques that subsequently extended to the neck, trunk, upper back, hands, lower legs, and feet.A skin biopsy supported the diagnosis of superficial EAC on clinicopathologic correlation.After limited improvement with topical therapies and oral prednisolone, she received four weekly doses of empiric oral fluconazole 150 mg without adverse effects.The eruption improved, and approximately five months after treatment discontinuation, she remained clear apart from residual post-inflammatory hyperpigmentation.The temporal association suggests a possible treatment response; however, the absence of pretreatment mycologic testing and the possibility of spontaneous remission limit causal interpretation.

Source: Cureus

DOI: 10.7759/cureus.118006

Authors: Sehrish Bakhsh, Mohammad Almazied, Ohud Alghudifi, Fares Alammari

Institutions: Alfaisal University, Security Forces Hospital, King Fahd Medical City

Language: English

Topic: Skin Diseases and Diabetes

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7222741253