Association of Score for Allergic Rhinitis with Serum Total IgE and Clinical Characteristics in Patients with Allergic Rhinitis
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Allergic rhinitis (AR) is a common immunoglobulin E (IgE)-mediated disorder with variable clinical expression. The Score for Allergic Rhinitis (SFAR) is a practical screening and probability tool, while serum total IgE may provide complementary information regarding systemic atopic activity. This study assessed the association between SFAR score, serum total IgE, and selected clinical characteristics in patients with AR. Methods: This case-control study included 33 patients with clinically diagnosed AR and 33 apparently healthy controls . SFAR was recorded for all participants. Patients underwent structured clinical assessment, skin prick testing, measurement of serum total IgE by enzyme-linked immunosorbent assay. Associations of serum total IgE with SFAR score, family history,identifiable allergy triggers were analyzed. Results: Mean SFAR score was significantly higher in patients than controls (9.33±1.38 vs. 2.41±1.05; P<0.001). Among patients, SFAR ranged from 7 to 13, with 66.6% scoring between 8 10. Serum total IgE showed a strong positive correlation with SFAR score (r=0.682, P<0.001). Patients with a positive family history had significantly higher serum total IgE than those without (412.6±128.4 vs. 271.4±94.8 IU/mL; P=0.003). Serum total IgE was also significantly higher in patients with identifiable allergy triggers than in those without recognized triggers (398.8±121.6 vs. 238.5±82.9 IU/mL; P=0.001). Conclusion: SFAR scores were substantially higher among patients with AR than controls were positively correlated with serum total IgE. Higher total IgE was also associated with positive family history identifiable triggers. These findings support interpreting SFAR serum total IgE as complementary clinical information rather than as direct measures of AR severity.
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7222867300