Histophysiology of the Acinus. Lung Regeneration and Transplantation
Year: 2026
Type: article
Abstract: This article provides a detailed examination of the histological structure, cellular composition, and histophysiological characteristics of the acinus—the primary structural and functional unit of the lung. It analyzes the roles of alveolar epithelium (type I and type II alveolar epithelial cells), capillary endothelium, the interstitium, and alveolar macrophages in processes such as gas exchange, surfactant synthesis, fluid balance, and local defense mechanisms. Furthermore, the article explores the physiological renewal of lung tissue and the mechanisms of regeneration following injury—involving type II alveolar epithelial cells, basal cells, bronchoalveolar stem cells, and regenerative niches—as well as the consequences of impaired regeneration (such as fibrosis and emphysema). It also addresses the histological and immunological foundations of lung transplantation, potential complications, and contemporary developments in the field, including *ex vivo* perfusion, bioengineering, organoids, and xenotransplantation.
Authors: Ergasheva, Munis, Saidov, Shoxrullo
Institutions: Termez State University, Tashkent Medical Academy
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7222871372
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