Intraoperative hemodynamic changes in patients receiving dexmedetomidine for general anesthesia.
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background Dexmedetomidine is a selective alpha-2 adrenergic agonist used primarily for intravenous sedation in intensive care units and during surgical or diagnostic procedures. Methods This prospective randomized study was carried out on 90 adult patients aged 65 years and older who presented to the operating room for surgery under general anesthesia. Patients were divided into two equal groups. Group (A) received general anesthesia after infusion of normal saline, while group (B) received general anesthesia after a loading dose of dexmedetomidine 0.6 µg/kg. Results There was a statistically significant decrease in hemodynamic parameters observed in the two groups after induction of anesthesia. Dexmedetomidine administration resulted in a further significant decrease in these parameters when compared to the control group. These changes were not clinically significant, as the values remained within normal ranges. This effect may be beneficial in elderly patients undergoing surgery under general anesthesia. Conclusion Dexmedetomidine provided superior hemodynamic stability compared with the control group.
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7222872809