Bipolar Disorder as Oscillatory Regime Instability
Year: 2026
Type: article
Abstract: Energetic Switching, Affective Threshold Dynamics, and the Breakdown of Mood-State Constraint within Informational Nosology Bipolar disorder is clinically defined by recurrent episodes of mania or hypomania and depression, with intervening periods of variable stability. Existing accounts correctly emphasize circadian vulnerability, reward hypersensitivity, monoaminergic dysregulation, and kindling over successive episodes. What they often leave under-specified is the systems-level architecture that makes a brain capable of crossing, locking into, and later exiting radically different affective operating regimes. This monograph formalizes bipolar disorder within Informational Nosology as an oscillatory regime-instability problem rather than as a simple excess or deficit of mood. The core claim is that bipolar illness reflects failure of the constraints that normally keep affective state transitions bounded, reversible, and metabolically affordable. Under converging circadian, sleep, energetic, and stress loads, the system becomes prone to threshold crossings into high-gain expansive regimes and low-gain depleted regimes. Mania is read as a high-throughput, low-inhibition operating mode with compressed valuation and accelerated commitment; depression as a protective or exhausted low-throughput mode with narrowed affordance and elevated withdrawal. The disease process is therefore not only episodic content, but progressive alteration of switching thresholds, recovery capacity, and inter-episode stability. The account is non-substitutive. It does not displace lithium-response biology, circadian medicine, or clinical staging. It relocates them within one dynamical language used across the Nosology corpus: energetic headroom, threshold mechanics, noise, precision, and the maintenance of operational constraint. Bipolar disorder is demarcated from schizophrenia by the preservation of a different relation between uncertainty and rigid crystallization, from autism by its acquired episodic switching architecture, and from unipolar depression by the bipolar capacity for high-gain expansive departure. Empirical signatures and falsification criteria are stated explicitly. Highlights: Bipolar disorder is formalized as oscillatory regime instability, not merely as alternating excess and deficit of mood. Core mechanism: failure of constraints that keep affective transitions bounded, reversible, and metabolically affordable. Mania and depression reinterpreted as distinct operating regimes — high-gain expansive versus low-throughput depleted — with progressive threshold and recovery effects. Clear demarcation from schizophrenia, autism, unipolar depression, and the gradual neurodegenerative portals. Non-displacement stance: circadian, pharmacological, and staging evidence remain intact; the contribution is a unifying dynamical architecture. Keywords: bipolar disorder; mania; depression; circadian rhythms; energetic switching; threshold dynamics; mood instability; informational nosology; systems neuroscience; kindling
Author: Marom, Ariel
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7222878351
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