Comparative Evaluation of Renal Resistive Index and Serum Calcium, Phosphorus, and Parathyroid Hormone Levels in Diabetic and Non-Diabetic Kidney Disease
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: The Doppler-derived renal resistive index (RRI) reflects intrarenal vascular mechanics and systemic hemodynamics, offering prospective clinical value in nephropathy. Objectives: To investigate how RRI metrics correlate with serum levels of parathyroid hormone (PTH), calcium, and phosphorus across diabetic and non-diabetic chronic kidney disease (CKD) cohorts. Patients and methods: A cross-sectional cohort of 100 adult CKD subjects (50 diabetic kidney disease [DKD], 50 non-diabetic CKD) underwent standardized renal duplex ultrasonography alongside serum biochemical profiling for calcium, phosphate, and intact PTH. Results: In DKD patients, right-sided RRI (RRI-Rt) correlated directly with serum phosphate (r = 0.302, p = 0.033) and PTH (r = 0.479, p = 0.001). In non-diabetic CKD, RRI-Rt displayed an inverse relationship with total calcium (r = -0.662, p < 0.001) alongside robust positive relationships with phosphate (r = 0.787, p < 0.001) and PTH (r = 0.799, p < 0.001). Left-sided RRI (RRI-Lt) mirrored these bilateral associations. In the diabetic population, RRI-Lt was positively correlated with phosphorus (r = 0.354, p = 0.012) and PTH (r = 0.386, p = 0.006), while its correlation with calcium did not reach statistical significance. In the non-diabetic group, RRI-Lt showed a strong significant negative correlation with calcium (r = -0.645, p < 0.001), and strong significant positive correlations with phosphorus (r = 0.782, p < 0.001) and PTH (r = 0.797, p < 0.001). Conclusion: Bilateral RRI values parallel hyperphosphatemia and secondary hyperparathyroidism in both diabetic and non-diabetic renal populations, demonstrating enhanced magnitude in non-diabetic CKD.
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7222879370