Work

Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel

Year: 2026

Type: article

Abstract: Six previously undescribed compounds, together with twelve known compounds, were isolated from Sinomenium acutum . The structures of the unreported compounds were determined by comprehensive spectroscopic data analysis, 13 C NMR calculations followed by DP4 + analysis, ECD calculations, and single-crystal X-ray diffraction analysis. Nine compounds exhibited more potent anti-inflammatory activities than the positive control indomethacin. The structure–activity relationship of the isolates with anti-inflammatory effects was elucidated, providing some useful clues for designing and developing structurally novel anti-inflammatory drugs. Furthermore, five compounds reversed the paclitaxel resistance in paclitaxel-resistant cervical cancer cells HeLa/PTX. The combination of compound 4 and paclitaxel promoted cancer cell apoptosis.

Source: Natural Products and Bioprospecting

DOI: 10.1007/s13659-026-00652-w

Authors: Xilei Wang, Chengjing Zhu, Xinyu Du, Qiang Wang, Jianqing Yu

Institutions: Wuhan University, Zhongnan Hospital of Wuhan University, South Central Minzu University

Language: English

Topic: Phytochemistry and Biological Activities

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China