Work

Multicomponent reactions for DNA ‐encoded library construction: Scaffold diversity and reaction engineering strategies

Year: 2026

Type: article

Abstract: DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp 3 ‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on‐DNA MCR scope to previously incompatible transformations without compromising DNA integrity. This review summarizes these advances and highlights stereoselectivity and biological validation as key directions for future development of acyclic and on‐DNA MCR methodologies.

Source: Bulletin of the Korean Chemical Society

DOI: 10.1002/bkcs.70230

Authors: Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim

Institutions: Korea Research Institute of Chemical Technology, Korea University of Science and Technology

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,470

Funder: National Research Foundation