Work

Predicting long-term survival in primary myelofibrosis

Year: 2026

Type: article

Abstract: We interrogated data from 217 subjects with primary myelofibrosis (PMF) diagnosed before 2001 to identify covariates at diagnosis associated with long-term survival. Forty-one survived more than 25 years. Long-term survivors were more often female, younger than 50 years and less likely to have anemia, splenomegaly, increased blood CD34-positive cells, a JAK2 V617F variant, and more likely to have grade-0 bone marrow fibrosis and increased platelets. In multivariable logistic regression analyses, age <50 years, platelet count >450 × 10⁹/L, and grade-0 bone marrow fibrosis independently predicted long-term survival. These co-variate associations were confirmed in Cox regression with landmark analyses. Long-term survivors had a lower cumulative incidence of anemia and thrombocytopenia during follow-up. Identifying long-term survivors at diagnosis provides clinically meaningful prognostic information in PMF and may influence therapy decisions.

Source: Leukemia

DOI: 10.1038/s41375-026-03177-w

Authors: Giovanni Barosi, Vittorio Rosti, Annalisa De Silvestri, Robert Peter Gale

Institutions: Policlinico San Matteo Fondazione, Imperial College London

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190