Work

STING deficiency extends median lifespan and mitigates age-related liver pathology in mice

Year: 2026

Type: preprint

Abstract: The cGAS-STING pathway is a major driver of chronic inflammation. While acute STING inhibition can reduce neuroinflammation and tissue damage, its long-term impact on longevity remains unknown. Here, we demonstrate that genetic deletion of STING extends median lifespan in mice. This survival benefit is accompanied by a marked resistance to age-related hepatic decline. Our findings demonstrate that targeting STING is a promising therapeutic target to extend healthy lifespan.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.10.16.759663

Authors: John C. Martinez, Sei Joong Kim, Joseph Cutting, John M. Sedivy, Andrei Seluanov, Vera Gorbunova

Institutions: University of Rochester, Brown University, University of Rochester Medicine

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7222929510