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Vitamin K2 ameliorates pregnancy‐ and lactation‐associated osteopenia and postpartum depression

Year: 2026
Type: article
Abstract: Vitamin K2 (VitK2) supplementation ameliorates comorbid pregnancy- and lactation-associated osteopenia (PLO) and postpartum depression (PPD). These improvements are accompanied by reduced relative abundance of Bacteroides uniformis (B. uniformis) and lower serum deoxycholic acid (DCA) levels. DCA inhibits osteoblast differentiation, promotes osteoclast differentiation, and contributes to an imbalance between hippocampal glutamatergic and GABAergic signaling. Maternal VitK2 supplementation also improves offspring cognition. These findings suggest that modulation of the gut microbiota–bile acid axis may contribute to the beneficial effects of VitK2, supporting the potential of VitK2 as a therapeutic agent for PLO and PPD.
Source: iMeta
DOI: 10.1002/imt2.70180
Authors: Wanqiong Yuan, Jing Hang, Jialin Jia, Jie Huang, Xuanqi Zheng, Huan Wang, Tong Wu, Hao Liu, Junxiong Zhu, Chenggui Zhang, Jinwen He, Yundi Zhang, Hong Wang, Xin Xiong, Na He, Haofan Bai, Jiamin Yan, Huijie Leng, Weili Zhu, Yingsheng Xu, Jie Shi, Chunli Song
Institutions: Ministry of Education of the People's Republic of China, Peking University Third Hospital, Peking University, Capital Medical University, Beijing Chao-Yang Hospital, Capital Medical University, Second Affiliated Hospital of Zhejiang University, Zhejiang University, Shandong Provincial Hospital, Shandong First Medical University
Language: English
Field: Nursing
Open Access status: gold
Estimated APC paid: $1,320
OpenAlex ID: W7222931651
FWCI:
Cites: 19
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Related to: 10