Year: 2026
Type: review
Abstract: Recognition of pathogens by immune receptors is essential for immune response activation in plants. The NLR (Nucleotide-binding, Leucine-rich repeat) family of intracellular immune receptors recognise the presence of pathogens from within host plant cells. Some NLRs are exclusively 'paired,' and require each other for function. With the pathogen sensing and immune activation function separated between the 'sensor' and the 'executor' NLR, the paired NLR system is promising target for engineering for broad spectrum disease resistance. Here, we review our current understanding of the diversity, molecular mechanism, and evolution of Arabidopsis paired NLRs with N-terminal TIR (Toll, Interleukin-1 receptor) domains (TIR-NLRs). We conclude with examples of paired TIR-NLRs beyond Arabidopsis and Brassicaceae species.
Source: Frontiers in Plant Science
Authors: Hayden Burdett, Tana L. Holmes, Hee-Kyung Ahn
Institution: University of Edinburgh
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Royal Society
OpenAlex ID: W7222940959