Comparison of Survival After Radical Hysterectomy or Radical Radiotherapy Among Patients with Different Histological Types of Locally Advanced Cervical Cancer: Analysis of SEER Data Using Propensity Score Matching
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: To compare survival outcomes of locally advanced cervical cancer patients with different histological types treated by radical surgery or radical radiotherapy.Method: Data for United States residents diagnosed with locally advanced cervical cancer between 2000 and 2022 were extracted from the Surveillance, Epidemiology, and End Results database. Overall survival and cancer-specific survival were compared using multivariable Cox proportional hazards regression. To minimize baseline differences, propensity score matching was utilized to pair patients from each group.Result: After propensity score matching of 5,058 patients with squamous cell carcinoma, surgery was associated with significantly better overall survival when disease was in stage IB3 (HR 0.70, 95% CI 0.50–0.97), but not when it was in other stages. Cancer-specific survival did not differ significantly between the two treatments at any disease stage. After propensity score matching of 1,345 patients with adenocarcinoma, surgery was associated with significantly better overall survival in stages IB3 (HR 0.46, 95% CI 0.28–0.77) or IIA2 (HR 0.38, 95% CI 0.15–0.96). It was also associated with significantly better cancer-specific survival in stages IB3 (HR 0.51, 95% CI 0.29–0.90), IIA2 (HR 0.22, 95% CI 0.07–0.76) or IIB involving tumors < 4 cm (HR 0.21, 95% CI 0.07–0.62).Conclusion: Surgery may lead to better overall survival than radiotherapy in stage IB3 squamous cell carcinoma. For adenocarcinoma, surgery may lead to better overall and cancer-specific survival than radiotherapy in stages IB3 or IIA2, and better cancer-specific survival in stage IIB involving tumors < 4 cm.
Source: Cancers
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W7222945656