Year: 2026
Type: preprint
Abstract: Single-cell Hi-C, spatial Hi-C and chromatin tracing measure the same genomes in incompatible formats. ChromData, one data model, indexes all three by cell and genomic bin; an open-source toolkit, linked browser and 22-dataset atlas build on it. Applied to ten mouse brain datasets of all three assays, the same calls rank cell types alike by short- over long-range proximity, and contact-based reconstructions largely place cell-type differences where imaging does.
Authors: Lu Zhang, Yu Chen, Quan Zhong, Weize Xu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7222948013