Work

In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions

Year: 2026

Type: article

Abstract: Oxidative stress, bacterial infection, and persistent inflammatory responses are key inhibitory factors for chronic wound healing, yet most conventional dressings fail to simultaneously address these pathological barriers. This study presents a multifunctional composite film incorporating manganese-curcumin (Mn-Cur) nanozymes prepared via a facile, carrier-free synthesis. These nanozymes exhibit dual superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities, enabling efficient elimination of superoxide anion radicals (•O 2 - ) and hydrogen peroxide (H 2 O 2 ). A rapid Prussian blue (PB) coating is introduced onto the Mn-Cur surface to enhance biocompatibility and confer photothermal antibacterial capability, forming Mn-Cur@PB (MC@PB) nanocomposites. The engineered nanozymes efficiently scavenge excess reactive oxygen species (ROS), exert potent antibacterial activity, and attenuate pro-inflammatory macrophage activation while inducing an immunoregulatory phenotype. The MC@PB nanocomposites are subsequently incorporated into a silk fibroin (SF)/polyvinyl butyral (PVB) matrix and cast into an in situ-forming wound dressing (denoted SPMP), bridging nanomaterial design and practical wound management. In vivo evaluation using infected diabetic wound models confirms that, under near-infrared (NIR) irradiation, the SPMP dressing effectively eliminates bacteria, alleviates inflammation, facilitates collagen deposition and angiogenesis, and accelerates wound closure. This multifunctional SPMP film represents a promising candidate for clinical chronic wound treatment.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2026.103759