Work

Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues

Year: 2026

Type: article

Abstract: Focused ultrasound (FUS) enables non-invasive, spatially precise modulation of biological tissues. This protocol describes assembly, calibration, and implementation of a diagnostic ultrasound-guided FUS (dUS-FUS) platform for real-time targeting of superficial and deep tissues in small-animal models. We demonstrate reversible sciatic nerve modulation in a rat acute pain model and assess sensory and motor functions using behavioral tests. The platform provides a reproducible workflow for image-guided tissue modulation and can be adapted to diverse preclinical applications. For complete details on the use and execution of this protocol, please refer to Sangwan et al. 1 , 2

Source: STAR Protocols

DOI: 10.1016/j.xpro.2026.104900

Authors: Namrata Sangwan, N. Chris Chaggares, Zahra Torbatian, Thomas Anthony Anderson

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,550