Case Report: Long-term survival in FIGO stage IVB small cell carcinoma of the ovary, pulmonary type following complete cytoreduction and platinum re-challenge
Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Small cell carcinoma of the ovary, pulmonary type (SCCOPT), is a rare and highly aggressive malignancy with poor prognosis. Long-term survival in advanced-stage disease has rarely been reported. Case presentation: A 55-year-old postmenopausal woman presented with FIGO stage IVB SCCOPT accompanied by extensive peritoneal carcinomatosis and a solitary liver metastasis. No pulmonary lesion suggestive of primary lung malignancy was identified on CT, PET/CT, or chest radiography. She underwent aggressive primary cytoreductive surgery achieving complete macroscopic resection (R0), followed by four cycles of cisplatin and etoposide (EP). Sixteen months after diagnosis, isolated intracranial recurrence with multiple brain metastases were successfully treated with radiotherapy. Twenty-one months after diagnosis, systemic recurrence involving multiple liver metastases and a spinal metastasis was treated with six cycles of EP re-challenge, resulting in a marked radiologic response and subsequent durable disease control. The patient remained alive without clinical evidence of disease progression at the latest follow-up, 104 months after diagnosis. Conclusions: This case suggests that prolonged survival may be achievable in selected patients with advanced SCCOPT through aggressive multimodal treatment. Complete cytoreductive surgery, platinum-based chemotherapy, including EP re-challenge following a prolonged platinum-free interval and previous response to platinum-based chemotherapy, and timely local treatment of metastatic lesions may contribute to durable disease control.
Source: Frontiers in Oncology
Institution: Daegu Catholic University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7222957448