Work

Design, synthesis, and anticancer evaluation of Biginelli-derived DHPM–amide hybrids bearing clinically inspired kinase-directed pharmacophores: EGFR docking and DFT studies

Year: 2026

Type: article

Abstract: = 3.155 eV) and are reported as a physicochemical description only, without implying a causal link to cellular activity. Normal mode analysis indicated conformational stability of the 10b-EGFR complex, collectively identifying 10b as a promising lead for further optimisation and mechanistic evaluation, for which direct EGFR kinase assays remain necessary.

Source: RSC Advances

DOI: 10.1039/d6ra08838d

Authors: Sagar P. Kothadiya, Jay B. Maheta, Darshna K. Lakhnotra, Yogesh O. Bhola, Sureshkumar B. Koradiya

Institutions: Atmiya University, Shri Govind Guru University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7222958113