Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Introduction Cognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals. Methods Sixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome. Results Higher mean performance was associated with greater hippocampal volume ( β =0.24, p =.03), while memory IIV was not ( β =0.028, p =.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ( β =-0.34, p <.01), while mean performance was not ( β =-0.07, p =.52). Discussion Memory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.
Source: medRxiv
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7222974957