Work

Functionalized bioresorbable biliary stents: materials design, coating engineering, and clinical translation

Year: 2026

Type: review

Abstract: , and expected real-bile degradation behavior, and critically evaluate the trade-offs among radial force retention, flexibility, fatigue resistance, radiopacity, drug release, biofilm resistance, manufacturability, and clinical readiness. Current evidence suggests that polydioxanone (PDO)- and copolymer-based designs may be more suitable for benign or post-surgical indications requiring temporary support, whereas malignant obstruction may require longer patency, stronger radial force, and carefully controlled antiproliferative or chemotherapeutic release. However, available human data include selected cohorts and registries but remain limited in comparative strength, so claims regarding long-term efficacy, quality of life, and cost-effectiveness should remain cautious until larger comparative trials are available.

Source: RSC Advances

DOI: 10.1039/d6ra06308j

Authors: Bowen Wang, Wei Gong

Institutions: Shandong Provincial Hospital, Shandong First Medical University

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042