Work

Cellular-resolution three-photon ultra-deep imaging (TrUDI) of neuronal population activity at 2-mm depth in the mammalian brain

Year: 2026

Type: article

Source: Nature Methods

DOI: 10.1038/s41592-026-03251-2

Authors: Kalyan Santra, Kevin Barber, Francesca Logiacco, M. Agustina Frechou, Arash Bellafard, Jyun-you Liou, Alipasha Vaziri

Institutions: Rockefeller University, Max Planck Institute for Biology of Ageing, University of California, Los Angeles, Weill Cornell Medicine

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: In vivo Imaging of Neuroactivity in the Deep Forward Scattering Regime Using Speckle Identification and Demixing (SPID) Microscopy, Lensless, high-speed and multi-region volumetric Ca2+ imaging of up to 1cm2 brain surface across model animals, Optimization, application and dissemination of high-speed hybrid multiphoton volumetric imaging technologies, Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-Linking, Optimization, Application, and Dissemination of Imaging Modules for High-speed Mesoscopic Volumetric Recording of Neuroactivity in Scattering Brains

OpenAlex ID: W7222978755

FWCI:

Cites: 74

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Related to: 10