Work

A siderophore-independent lanthipeptide carrier enables Trojan-horse delivery of antibacterial cargoes into Gram-negative bacteria

Year: 2026

Type: article

Abstract: and enhanced cefiderocol activity under co-treatment conditions. These results establish noursin as a functional lanthipeptide-derived Trojan horse carrier and highlight structurally complex RiPPs as underexplored delivery scaffolds for combating Gram-negative bacterial pathogens.

Source: Chemical Science

DOI: 10.1039/d6sc05931g

Authors: Boning Wang, Yundan Zheng, Erpeng Guo, Yewen Juan, Yida Han, Yuqing Li, Yeying Ma, Wenya Zhou, Xu Zhen, Ran Xie, Tong Si, Huan Wang

Institutions: Nanjing Drum Tower Hospital, Nanjing University, Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Shenzhen Institute of Synthetic Biology

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, Natural Science Foundation of Jiangsu Province, Nanjing University, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities

Awards: G1207702473, G6569951564, G7131119091, G7842690868, G8126516475

OpenAlex ID: W7222994009

FWCI:

Cites: 26

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Related to: 10